Temporary Research Associate (21-15762)
Job Description
Job Description: Job Description
Research Associate, Translational Research
Duration = 12 months from start date Typical Daily
Work Hours = 8am to 5pm (some flexibility in start / end times); 8 hrs / day & 40 hrs / Week Weekend & OT work = None
100% onsite work
The Mechanisms of Cancer Resistance (MoCR) Thematic Research Center (TRC) at Client is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at MoCR TRC focus on Client tumor intrinsic targets and pathways for tumors that are refractory to current immuno-oncology and oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo, ex vivo models of cancer biology to identify and validate targets. MoCR TRC Translational Research at Client
Our translational research group in San Francisco focuses to develop target validation approaches, define appropriate disease models, and collaborate closely with colleagues in in vivo Pharmacology, Translational Medicine, Informatics and Predictive Sciences, as well as Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We also work with Clinical Pharmacology to define starting doses and schedules for dose escalation in Phase 1 studies. Rational combinations of Client molecules is also a focus.
We are seeking a highly motivated, innovative, collaborative individual to join our translational research group. The successful candidate will have experience performing laboratory work, including handling cells in tissue culture and preparing/analyzing DNA, RNA and protein samples, using a variety of methodologies. The qualified candidate will have experience running cell-based assays, using various technologies. The candidate will use current or new techniques to address questions of drug mechanisms of action and drug sensitivity / resistance. Experience in immuno-oncology, cell signaling and/or with flow cytometry is a plus.
Technical Skills: FOCUS ON THESE SKILLS • MOST IMPORTANT: Expertise in mammalian cell culture. Proficient in cell and molecular
techniques including DNA/RNA/protein preparation and analyses (RT-PCR, Western blot, etc),
flow cytometry.
• Core cell biology skills including cell-based assays to evaluate cell growth and death
Scientific Capabilities – The Successful Candidate Will be Expected to:
• Conduct experimental work independently, with accurate, detailed record-keeping
• Have excellent time-management and organizational skills
• Prepare and discuss scientific data in a clear, concise and accurate manner
• Have effective oral and written communication
2
• Have strong problem-solving skills
• Be flexible in case of changing priorities
• Set up and utilize a wide range of in vitro oncology models
• Execute experiments to characterize effects of small molecule inhibitors
• Be able to identify scientific and technical problems and suggest potential solutions
Below Experience is a PLUS: • Cell-based high throughput assays, siRNA, shRNA, CRISPR etc.
• Microscopy, immunoprecipitation
• Cell migration assays, Quantigene assays, ELISA etc.
• Immunofluorescence techniques
• Knowledge of oncology and/or immunology
Requirements & Education The position requires a
• Bachelor’s degree with at least 6 years lab work experience in cell / molecular biology
Or a
• Master’s degree in cell / molecular biology with at least 4 years lab work experience
Or a
• PhD degree in cell / molecular biology
How to Apply
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