Job Description

Expert Scientist, Downstream Process Development, Mammalian Expression Technology Center of Excellence

Are you energized by a challenging role in biology, where scientific demand is driving team growth?  If so, this Expert Scientist role would be a great opportunity to consider.

The Mammalian expression technology Center of Excellence (Technical Research & Development, GSK Vaccines) is seeking an enthusiastic, experienced, and motivated Expert Scientist with a strong understanding and experience in separation technology to drive downstream process development for CHO protein subunit and mRNA – based vaccines.  Located in Rockville, MD, the position will contribute to the success of the GSK CHO protein subunit and mRNA based platform.

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…

CHO protein subunit-based vaccine platform specific responsibility:

• Kick-start design and development of backbone downstream processes CHO protein subunit vaccine antigen for company pipeline projects in early stage up to Phase I.
• Facilitate process transfer to development units for late-stage development/life cycle management in Global Cell& Viral Drug Substance organization.
• Streamline/harmonizing vaccine antigen development workflows related to downstream process development and tech transfer.
• Lead the downstream process fit evaluation for CHO cell line development and clone selection.
• Lead the tool antigen production to support antigen design and proof-of-concept study in preclinical/early discovery function.

mRNA based vaccine platform specific responsibility:

• Drive development & optimization of a clinical & commercial manufacturing processes for the purification of mRNA and DNA plasmid template
• Partner with mRNA downstream process development scientists from nucleic acids vaccines center of excellence to drive company pipeline project execution and mRNA separation technology innovation

Generic responsibility:

• Independently design and execute laboratory experiments.
• Partner with diverse team members from various functions, multiple countries, and members at various levels in organization
• Benchmark specific technologies in own functional area to bring technology to state of the art
• Solve complex problems through analytical thinking to identify and understand alternatives using knowledge gained through formal education, experience, and sound judgment
• Prepare oral and written reports to communicate scientific findings and to support project documentation and CMC submissions
• Comply with data integrity requirements for laboratory work

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Advanced Degree (Master with 6 years or PhD with 2 years of relevant experiences) in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, Bioengineering, or a related scientific field
• 2 years experience in protein and mRNA purification or experience of purification of biomolecule
• 2 years experience with different purification techniques such as chromatography, tangential flow filtration (TFF) and associated instrumentation such as Akta chromatography systems and Unicorn software
• 2 years experience with bioanalytical assays associated with purification processes, such as SDS-PAGE, Western blotting, HPLC, etc.
• 2 years experience in research and development in a Biopharmaceutical industry or government laboratory setting.
• 2 years experience in experimental design and be able to independently execute laboratory experiments

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Communicate effectively with regular verbal and formal updates to project teams and management.
• Understanding of purification of biologics, specifically complex protein subunit and large size mRNA, including process scale-up
• Experience with different purification techniques such as Tecan high-throughput miniature chromatography system
• Understanding of Quality by Design and the development of a process control strategy
• Design and execute DOE studies & high-throughput screen for purification process improvements and advancements including parameter optimization, scale-up, process window determination and process capability evaluation
• Strong hands-on experience with a wide range of purification techniques for large molecules( e.g. protein subunit and large size mRNA)  including affinity capture, ion exchange and hydrophobic interactions.
• Knowledge of technology transfer and GMP manufacturing
• Be able to rapidly acquire project understanding and apply professional knowledge to project improvement.
• Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions

How to Apply

Job Categories: Equal Opportunities. Job Types: Full-Time. Salaries: Not Disclosed.

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