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20 Dec 2020

Full-Time Senior Scientist – AAV Analytical Development – Biophysical Assays

UCB Bioscience – Posted by UCBdenise Boston, Massachusetts, United States

Job Description

To strengthen our Gene Therapy Vector Core Team, based in our Boston Office, in Bedford MA, we are looking for a talented individual to fill the position of: Senior Scientist – AAV Analytical Development – (Biophysical Assays).

As a Senior Scientist you will assist in the area of biophysical characterization and assay development for biologics. This individual will support multiple therapeutic gene therapy programs by leading development of methods for assessing product quality for AAV used in research and initial process development.

You will contribute by:

  • Establishing multiple methods for assessment of viral capsid protein content, composition, and quality (ELISA, HPLC, CE, AUC, LC-MS, etc)
  • Utilizing antibody and chromatography based methods for impurity detection and characterization from multiple steps in viral process development
  • Incorporating improvements to standard testing methods to allow for high throughput or more accurate quantification
  • Responsible for testing schedule and data reporting along with maintenance of multiple analytical methods
  • Collaborating with the upstream, downstream and vector biology teams
  • Show the ability to function independently and cross functionally across various UCB teams (medicinal chemists, cell biologists, disease area exerts, antibody engineers, etc)
  • Show the ability to manage priorities, and engage/communicate in a multidisciplinary environment

Interested? For this position you’ll need the following education, experience and skills:

      Minimum Qualifications:

  • Ph.D in molecular biology, biochemistry, genetics, or virology with 3+ years experience. MS may be sufficient based on experience.
  • Hands-on experience developing biophysical based methods for protein or impurity quantification (size exclusion chromatography, capillary electrophoresis, analytical ultracentrifugation, etc)
  • Additional experience with nucleic acid based analytical methods for viral vectors preferred
  • Previous development or qualification of methods for AAV or viral vector products is a plus

Why you should apply

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.


If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.


About Us

At UCB, we come together every day to work, laser-focused, on a simple question: How will this create value for people living with severe diseases? By putting patients at the heart of everything we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees worldwide operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases. We are looking for people with passion and empathy who develop a real understanding of patient’s needs and can deliver thoughtful solutions to decisionmakers across the heath care ecosystem.

Curious to know more? Please visit our website

How to Apply

Job Categories: Equal Opportunities. Job Types: Full-Time. Salaries: Not Disclosed.

Job expires in 52 days.

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