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22 Feb 2021

Temporary Senior Scientist (21-04415)

Axelon Services Corporation – Posted by iris.chen@axelon.com San Diego, California, United States

Job Description

The position requires a bachelor’s degree in scientific discipline and 10+ years of laboratory experience or a Master degree with at least 6-8 years of experience. Preferably a PhD with industry experience or with Postdoc in academic lab.

Summary/Scope:
GPCR biochemist /molecular pharmacologist/structural biologist

A highly talented and motivated membrane protein or GPCR protein chemist/biochemist/structural biologist is sought to assist a GPCR structural biology team with assay development, purification and crystallization of challenging membrane protein samples. The successful candidate will work within various discovery project teams and will have the opportunity to work on a state-of-the-art drug discovery environment, where discoveries can be immediately translated to treatments for serious diseases.

Responsibilities will include, but are not limited to, the following:
1. Independently design expression constructs and purify protein samples and their complexes for crystallography, assays and cryo EM
2. Design and develop biochemical and biophysical assays to characterize protein complexes
3. Analyze, document and present data in an organized and timely manner
4. Work with other members of the structural biology team to obtain diffracting crystals for multiple projects to support SAR studies
5. Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude

Skills/Knowledge Required:
1. Excellent protein purification skills and knowledge of all techniques required to deliver high quality protein samples suitable for crystallization and Cryo EM experiments
2. Excellent protein purification troubleshooting skills to purify challenging/Client targets
3. Characterization of protein samples in complex with small molecules and other protein partners
4. Knowledge or experience with biochemical assays (cell based assay experience is advantageous)
5. Experience with macromolecular crystallization and X-ray crystallography is advantageous
6. Knowledge or experience with X-ray crystallography data collection and analysis is desirable but not required
7. Experience with membrane protein purification and LCP crystallization is desirable but not required
8. Cryo EM experience is desirable but not required
9. Excellent communication, presentation, collaboration and organizational skills are required

Functional/Scientific/Technical Skills:
• Expert knowledge & demonstration of technical field.
• Generally independent in carrying out laboratory operations.
• Solid understanding of relevant scientific principles.
• Viewed as technically experienced and valued resource within department.
• Able to identify scientific and technical problems and potential solutions.

Tasks and Responsibilities:
• Execute experiments independently.
• Interpret and discuss data.
• Trouble shoot.
• Familiar with literature.
• Role models for other scientists.
• Communicate via meetings and reports.
• Responsible for the completion of assignments that have an impact on functional goals.
• Able to coordinate CRO services.

Discretion/Latitude:
• Works independently.
•Viewed as an experienced resource within their department.
• Provides input into experimental designs.

Creativity and Problem Solving:
• Improves efficiency and productivity within group or project.
• Understands departmental goals and development processes.
• Able to more fully interpret results and situations independently and articulate recommendations for resolution with strong scientific arguments.
• Recognizes risks and develops contingency plans.

Teamwork and Influence:
• Communicates with peers and supervisors.
• Begin to contribute to the achievement of workgroup/team goals.
• Key contributor to collaborative efforts.

Organizational Impact:
• Has a direct impact on department sub team or project team performance.
• Impact is achieved by helping lead workgroup(s).

Behavioral Competencies:
• Acts with integrity • Analysis of issues
• Building relationships • Coaching and developing others
• Delivers presentations • Develops systems & process
• Fosters open communication • Influence others
• Innovates • Manages execution
• Planning • Use sound judgment.

How to Apply

Please send your updated resume to iris.chen@axelon.com

Job Types: Temporary.

Job expires in 75 days.

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