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17 Nov 2020

Full-Time Principal Scientist CADD

UCB Bioscience – Posted by UCBdenise Boston, Massachusetts, United States

Job Description

We are seeking an experienced Senior Principal Scientist CADD – AI Application Specialist to join our global Computer-Aided Drug Discovery team and broader research group in UCB’s growing US-based research hub in Bedford, MA. The Bedford site is home to a diverse group of research functions and teams such as Targeted-Protein Degradation, the DNA-encoded Library Platform, Gene Therapy, Protein production & purification, Biophysics and X-ray Crystallography.


This position is part of the global CADD team and an investment into chemistry-focused development and application of machine learning & artificial intelligence tools as part of our commitment to accelerate the speed and improve the quality of small molecule designs. The successful applicant will demonstrate excellent scientific judgement and with proven expertise and in-depth knowledge and hands-on experience in the field of Machine Learning (ML) and Artificial Intelligence (AI). You will be instrumental in implementing strategy, development and application of AI and advanced machine learning tools in small molecule drug discovery. You will work closely with our scientists across multiple departments and multiple research sites and collaborate with external academic and industrial partners.


You will contribute by:

  • Providing leadership and collaborating with other team members in the planning, implementation and execution of AI approaches for small molecule drug discovery, including compound property prediction/optimization, molecular design, retrosynthesis planning, chemistry-focused natural language processing & chemical structure perception, etc.
  • Providing scientific leadership in ML/AI for Chemistry and provide recommendations on emerging technologies and capabilities.
  • Proactively acquiring, developing and/or implementing relevant computational tools and workflows through independent research and internal/external collaborations.
  • Offering constructive challenge and advocate continuous improvement of CADD operation to enable effective drug discovery process.
  • Establishing effective cross-functional collaborations and communications
  • Demonstrating a high level of entrepreneurship and fosters in others a can-do and can-win attitude.


Interested? For this position, you’ll need the following education, experience and skills:


Minimum Qualifications:

  • Master’s degree required
  • 8+ years of industry experience in ML/AI, Computational Chemistry, Cheminformatics, Computer Science
  • 3+ years working with Deep Learning, neural network architectures including CNNs, RNNs, Reinforcement/Transfer Learning
  • 3+ years’ experience with at least one Deep Learning framework such as TensorFlow, Keras, scikit-learn or PyTorch
  • 5+ years of hands-on programming and scripting skills in Python, RD Kit and similar
  • Authored in scientific publications and/or patent applications.


Preferred Qualifications:

  • PhD preferred
  • Hands-on experience in applying artificial intelligence, machine learning and deep learning technologies to address challenges in chemistry and small molecule design
  • Excellent written and verbal communication skills in English
  • Knowledge of small molecule drug discovery
  • Able to create effective working relationships within a matrix working environment via influencing and networking.


Why you should apply:

At UCB, we strive to attract passionate and outstanding talents who thrive on change and are ready to bring real value to patients. Working for us you’ll discover a place where you can grow and express your full potential. We place an emphasis on innovation, collaboration and impact. Through meaningful recognition and a motivating work atmosphere, we aim to provide an optimal experience by caring about and valuing our employees – just as we do for the patients we serve.


If you believe you are the perfect match to join us on our pioneering adventure, then we invite you to apply and tell us more about your profile and motivation.



About Us

At UCB, we come together every day to work, laser-focused, on a simple question: How will this create value for people living with severe diseases? By putting patients at the heart of everything we do, our approach – from discovery to development to delivery – is continuously transformed and designed around patient needs and their journey.

With a team of approximately 7,500 employees worldwide operations in more than 40 countries, we are a global biopharmaceutical company investing more than a quarter of our revenue in cutting-edge scientific research. We are focused on addressing chronic, neurological, immunological, and bone diseases. We are looking for people with passion and empathy who develop a real understanding of patient’s needs and can deliver thoughtful solutions to decisionmakers across the heath care ecosystem.

Curious to know more? Please visit our website

How to Apply

Job Categories: Equal Opportunities. Job Types: Full-Time. Salaries: Not Disclosed.

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